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The decrease in the level of expression of genes responsible for the synthesis of superoxide dismutase increases with the increase in glutamine concentration

156 Besides, with the consumption of extracellular glutamine, GDH can also catalyze ammonia derived from glutaminolysis and -KG to support the synthesis of glutamate and downstream metabolites by reductive amination in a NADPH consumption manner to meet the cancer cells growth

Based on these findings, the FDA granted accelerated approval in 2024 to this combination therapy for KRAS G12C mutated CRC

[2]Collins, C. B., Riskowski, R. A., Ackerson, C.J. Radiofrequency remote control of thermolysin activity. Sci Rep 2021 Mar 16;11(1):6070. doi: 10.1038/s41598-021-85611-w

The iron moiety of hemoglobin can be oxidized to the Fe 3+ state to form methemoglobin